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Do You Have to Use Minoxidil Forever?

You’ve heard about Minoxidil, or maybe you use it to treat hair loss, and with daily applications, you’re wondering how long you have to commit to using Minoxidil. Applying the foam or liquid solution every day, and waiting hours for your hair to dry before styling, is painstaking. Which brings up an important question: Do you have to use Minoxidil forever? Or can you stop after you see results—if you see results?

In most hair loss cases, you do have to use Minoxidil forever to achieve and maintain hair growth. Otherwise, discontinuing could send your hair to the state it was in when you initially started treatment. In other words, hair loss would likely continue. However, there are some exceptions. 

To avoid wasting time and money chasing a treatment that may not work, it’s essential to explore your options. 

Daniel Alain can help you determine if Minoxidil is the right hair loss solution for you. But first, what causes hair loss, and how long will you have to use Minoxidil to see (and maintain) results?


HAIR LOSS CONDITIONS & THE AVERAGE MINOXIDIL TIMELINE

Minoxidil is an FDA-approved hair loss treatment sold by popular brand names like Rogaine®, Keeps, Hims, Hers, and Nioxin. Minoxidil may stimulate hair regrowth on the scalp for some men and women, but not all.

When it comes to hair loss, there are a plethora of causes—from over-styling and heat damage to dietary and biological reasons. Identifying the root cause can be tricky. 

According to the American Hair Loss Association, over 40% of women are struggling with some form of hair loss. As many as 70% of men will experience hair loss as they age, with many noticing signs before they’re even 21. Medications like Minoxidil may effectively regrow hair in genetic hair loss conditions.

Do you have to use Minoxidil forever? While discontinuing Minoxidil may be an option for some, it isn’t for most. Below, we’ll outline the most common hair loss conditions and give you an idea of how long you’ll need to take Minoxidil for each one.

Telogen Effluvium

Are we what we eat? Not exactly. But nutrition impacts every part of the body, hair included. Certain foods stimulate hair growth, while other foods can trigger hair loss. Telogen effluvium is the sudden onset of diffuse hair loss associated with diet and stress. It usually presents with excessive shedding triggered by low iron, thyroid issues, or crash diets. 

What can you do? Addressing the trigger is usually the first step in remedying hair loss. Once that’s been addressed, hair loss will slow down and eventually stop. An anti-hair shedding treatment for men and for women can also help to strengthen hair strands during vigorous activities like washing and styling, and give you shiny, gorgeous, volumized hair.

Excessive shedding is one of the first signs of the onset of genetic hair loss. If the hair loss is significant, Minoxidil could help to stimulate regrowth if it is determined the hair loss is due to genetics. Do you have to use Minoxidil forever in cases where hair loss is temporary? Usually, no. Once you isolate the trigger and make changes as needed, the shedding should minimize. It will only require long-term treatment for rarer cases of chronic telogen effluvium, where the entire scalp sheds excessively.

Anagen Effluvium

Anagen effluvium is sudden hair loss triggered by the impaired mitotic or metabolic activity of hair follicles. Huh? Essentially, this type of non-scarring alopecia is a common result of chemotherapy. 

In other words, chemo attacks all the rapidly dividing cells in your body, yes, even the healthy ones. Hair follicles, some of the fastest-growing cells in your body, are targeted just as much as cancer cells. Sadly, this often results in anagen effluvium or chemo-induced alopecia.

Battling cancer is extremely difficult, and dealing with hair loss on top doesn’t make matters easier.

While there is no way to prevent cancer-related hair loss, remember that it is temporary. In most cases, hair will regrow once you finish chemo. So what can you do in the interim to maintain your self-confidence and continuity with your image?

You may benefit from a hair topper or human hair wig, which can offer coverage to conceal hair loss as your body responds to chemo.

Alopecia Areata

Did you know that stress can cause hair loss? Alopecia areata is just that: an autoimmune response to high stress. It can occur anywhere on the body but typically presents in circular patches of hair loss along the scalp. The immune system attacks hair follicles and causes hair loss. Anyone can develop alopecia areata, but your chances are higher if it has affected someone in your family.

As far as treatment, the solution is easier said than done: minimize the stress. This is no easy feat—especially with the state of the world as of late (pandemic, inflation, war… it’s enough to make all of us lose our hair). But there are ways to reduce stress.

Identify your triggers and find an outlet that helps you relieve your stress. Go on a long walk, have a long chat with a good friend, listen to the Calm app, pet your favorite furry friend. By alleviating your stress triggers, the hair growth cycle can resume, sending more hairs into the growth phase (anagen), and you’ll start to see new growth in about 3-6 months. 

Corticosteroids (a class of steroid hormones) and Minoxidil are also effective in stopping the patches of hair loss from returning. Do you have to use Minoxidil forever with stress-related hair loss? If you can reduce your stress triggers, you can reduce Minoxidil treatments as your hair regrows.

Scarring Alopecia

Unlike other forms of hair loss we’ve discussed, scarring alopecia (cicatricial alopecia) is a rare inflammatory condition that destroys hair follicles and replaces them with scar tissue, making hair unable to regrow. Trauma such as scalp burns or severe infections can also cause scarring alopecia.

Unfortunately, there is no known cure for this type of hair loss.

While scarring alopecia is permanent and irreversible, you can take steps to reduce the amount of hair loss and severity of scarring. When combined with treatments like hair autografting (hair transplantation), Minoxidil has been shown to stimulate the growth of the remaining hair follicles. 

Do you have to use Minoxidil forever if you have scarring alopecia? Most of the time, yes. Since the scar tissue is permanent, you’ll likely have to use Minoxidil long-term to maintain results.  

Traction Alopecia

As the name suggests, traction (or mechanical) alopecia results from repeated trauma to the hair follicles. Unfortunately, many of today’s trending styles for women result in excessive tugging on the hair follicles. 

For instance, pulling your hair into tight hairstyles like braids or buns that cause excess strain on the scalp. That ultra-chic, famous Ariana Grande ponytail is a prime example. Fabulous? Absolutely. Damaging? Potentially. Over time, you may experience symptoms like irritation, hair thinning, redness, or hair loss along the hairline. 

You can prevent traction alopecia by making styling adjustments such as wearing looser hairstyles. However, repeated strain on the hair follicles can result in irreversible scarring alopecia. According to a 2019 study in the American Journal of Clinical Dermatology, Minoxidil can help to accelerate regrowth in early traction alopecia. Still, you should avoid it if the area is inflamed. 

So do you have to use Minoxidil forever if you have traction alopecia? Not usually. Once you’re satisfied with the growth and the hair loss has stopped, you can likely stop using Minoxidil. 

 


NOT SURE IF MINOXIDIL IS RIGHT FOR YOU? DOWNLOAD OUR GUIDE

 

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 DOES MINOXIDIL WORK FOR EVERYONE?

While Minoxidil can effectively remedy many hair loss conditions, it does not help everyone. That’s because there are specific components needed for Minoxidil to work. 

Minoxidil only works for those with genetic hair loss who also have SULT1A1 enzyme activity. These enzymes are found in the outer root sheaths of hair follicles. However, SULT1A1 levels vary from person to person.

Why does that matter? Because your scalp needs SULT1A1 activity to convert Minoxidil into its active form.

Minoxidil also works best within the early stages of hair loss as there is usually more hair to preserve, making the treatment more useful for people 40 and under. As mentioned before, you do have to use Minoxidil forever in many cases.

What if you’re using Minoxidil and aren’t seeing results?


 HOW CAN I TELL IF MINOXIDIL WILL WORK FOR ME?

Minoxidil Response Test | Daniel Alain

Daniel Alain’s Minoxidil Response Test (MRT) is the only product on today’s hair loss market that can tell you if your scalp has the right enzyme activity to respond to Minoxidil. 

 

For a long time, those struggling with hair loss were forced to wait 6-9 months before ever knowing if Minoxidil was working. It is a grueling waiting game. This is because up until now, there was no definitive way of testing for the presence of SULT1A1 enzyme activity.  

 

Thanks to our exclusive Minoxidil Response Test, you no longer have to wonder, “Will Minoxidil work for me?” Our patented test removes the guesswork by providing quick and accurate answers. Daniel Alain’s CLIA-certified lab analyzes your hair to determine if you have the enzyme activity necessary to respond to Minoxidil. 

 

Better yet, you’ll know in two weeks or less.

 

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 What else you can do to treat hair loss?

What if Minoxidil isn’t right for you? Other hair loss solutions can help to strengthen existing hair and reaffirm your confidence. 

From anti-hair shedding treatments to premium hair toppers and beautifully-crafted, human hair wigs that transform your confidence from within, here are some hair loss solutions worth exploring. 

Use an Anti-Hair Shedding Treatment

At Daniel Alain, we’ve created the world’s very first root-securing technology used exclusively in our hair fall treatment, INTACT. Our anti-hair shedding treatment for men and for women uses PiliLock Sevilla Orange Complex to keep hair intact at the root, even during high-shed activities like washing, brushing, and styling. This treatment the hair follicles at the root, locking the hair in place.

The best part? You will notice a difference after the very first use! 


 EXPLORE HAIR LOSS SOLUTIONS AT DANIEL ALAIN!

We’re champions of beautiful hair, always in your corner to provide education, solutions, and honest depictions of what to expect from hair loss. 

While waiting around for Minoxidil to work is a painstaking lesson in patience, it doesn’t have to be. You have the power to direct the course of your hair loss journey with effective solutions, such as our Minoxidil Response Test for men or for women or hair fall treatments. And we’ll stand beside you for every step of your journey.

Have more questions? Contact us to chat about your hair goals, or read the FAQs below.

 


 Frequently asked questions about minoxidil

Will Minoxidil Work Forever?

With some hair fall causes, you must use Minoxidil forever. Ongoing use is required for those struggling with androgenetic alopecia and progressive hair loss conditions. However, if you see results with Minoxidil, you should continue using it. Otherwise, your hair health may revert to the way it was when you started. 

What Happen If I Shop Using Minoxidil?

In most cases, your hair loss will likely progress. When you use Minoxidil for hair regrowth, your hair essentially becomes Minoxidil-dependent. By removing Minoxidil from your routine, one of two things can happen: your hair’s anagen phase will shorten, or hair will revert from the anagen phase to the telogen phase (shedding).

In other words, hair loss will resume to the way it was pre-Minoxidil treatment. In such cases, you do have to use Minoxidil forever.

Does Minoxidil Have Any Side Effects?

Common Minoxidil side effects include a dry or irritated scalp, UV sensitivity, burning, itching, and flaking. Hair can also grow in unintended areas like the chin or cheek. Women with color-treated hair can also experience more intense side effects like lightheadedness and irritation on the scalp. Side effects are limited and will subside when you take Minoxidil. 

If you experience nausea, weight gain, swelling, chest pain, or heart palpitations, you should immediately stop Minoxidil treatment and contact your physician.

Can I Use Minoxidil If I'm Pregnant?

While you do have to use Minoxidil forever to treat some hair loss conditions, its potentially harmful effects on unborn babies or breast milk are unknown. For that reason, you should check with your doctor before using Minoxidil while pregnant or breastfeeding.

Can I Use Minoxidil Long Term?

Yes, Minoxidil is safe to use long-term and is required for many hair loss disorders. It is the only FDA-approved topical hair loss treatment for men and women.

Does Minoxidil Lose Effectiveness Over Time?

No, Minoxidil does not lose effectiveness over time. Your hair will stabilize once it has reached its maximum regrowth potential. At that point, Minoxidil will maintain the regrowth that you have achieved.

How Long Until Minoxidil Starts Working?

It’s easy to wonder if Minoxidil is working because of how long it can take to see results. 

When you first start using Minoxidil, you might notice that shedding increases before it slows down. Don’t panic! This is completely normal. As the hair growth cycle purges old hair, it sends the follicles back into the growth stage. The initial increase in shedding is simply your hair growth cycle adapting to the introduction of Minoxidil and is usually a sign that it’s working. 

Once you shed the old hairs and begin producing new ones, you may notice more length and a feeling of thicker hair. You may see changes in as little as three months and full results after one year. 

Does Minoxidil Work the Same for Men & Women?

For the most part, yes. The main variation is that the 5% men’s formula contains propylene glycol. While this ingredient helps Minoxidil penetrate the scalp more deeply, it is significantly more irritating and harder to tolerate, often causing the side effect of trichosis in women—excessive hair across the face and body. Other than that, Minoxidil works the same by stimulating hair growth on a biological level. 

How Much Does Minoxidil Testing Cost?

The Daniel Alain Minoxidil Response Test for men and women retails for $139.00 (USD) plus taxes. 

 


 Where can i buy a minoxidil response test?

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Brittany P.
I had an amazing experience!

I had an amazing experience! Ashley was incredibly helpful! Love my new piece!

Hi Brittany! Thank you so much for your kind review. We truly appreciate you taking the time to share your experience. We’re delighted to hear that you had such a lovely visit and that our FOLLEA Expert, Ashley was able to provide with exceptional service. We hope you continue to love your new FOLLEA Style wig, and we’re always here if you need anything in the future!

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Daniel Alain
Samantha F.
Amazing Company

I recently lost my hair in a horse accident, but Daniel Alain was quick to help me out. I bought 3 toppers and I love all of them. They suit me extremely well, and I will forever be grateful. Thank you very much.

Hi Samantha! Thank you so much for sharing your experience. We're truly honored to be part of your hair journey and so happy to hear that you love your Follea by Daniel Alain hair toppers. Knowing they help you feel confident and comfortable means everything to us. Thank you for trusting Daniel Alain!

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Jessica A.
Ashley is wonderful!

Very impressed with the quality of service and quality of the hair piece!! Five stars!! Don’t waste time anywhere else.

Hello Jessica,

Thank you so much for sharing your experience with Ashley. We strive to be apart of every step of your journey, to ensure you have the best experience possible.

Love, The Daniel Alain Team

J
Daniel Alain
Jenna D.
Unbelievable Experience

I was new to alternative hair and hit my rock bottom and realized I couldn’t put off a wig any longer. Ashley is absolutely incredible. She’s patient, knowledgeable, and so accommodating. She knew how vulnerable I felt and allowed me to take my time and get a piece I would be happiest with.

I am so grateful for this experience and I’m glad I found follea before being too traumatized elsewhere!

Truly, stop looking and buy the wig.

Dear Jenna,
Thank you so much for sharing your consultation experience with Ashley. It brings us so much joy to know she was able to help you find a piece that is best for you. We strive to help women feel comfortable and confident during there hair journey.

Xoxo, The Daniel Alain Team

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Daniel Alain
Bridget H.
Very helpful

We’ve been seeing a lot of hair loss in our clients due to Covid. Intact has helped to significantly reduce the shed! Our clients love it and so does the salon plumbing!

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Daniel Alain
Tara T.
Fear to FABULOUS!!

Ladies, if you’re asking yourself…”why is this so expensive in comparison to other options?”…don’t and take the plunge. You will know why INSTANTLY when you open it up! This purchase is for YOU to gain your confidence back, to feel pretty and to walk with pride so it’s worth it! We all spend so much on nothing, our kids, stupid things…We are worth investing in ourselves! I’m a first time buyer of a wig and I’m 51 yo. No current cancer or no chemo, just ruined my hair with extensions for many years. I experienced so much denial, fear, and much sadness but…Janet, what an angel…walked me through it, didn’t pressure me and was so incredibly patient with answering all my questions…she made me come to the realization how bad extensions are on your hair and if I’m going to try and see if I can regrow my hair, I need to take the extensions out, allow my head and follicles to breath naturally….all sounds like a good idea right? It was hard for me to realize this and knowing that I’d have to rely solely on a wig now at 51yo! But! As I mentioned above, it is worth it and I feel fabulous! It is so natural looking, it moves with you, it’s comfortable, and not crazy hot! You can style it however you want! I never write reviews but felt this was probably the most important one I could ever write in an effort to help someone else either like me who was afraid of needing a wig, or someone who is simply considering a new one from this company. And most of all, you are never alone through this journey. Janet is reachable and so helpful even after you receive it! I’m on the other side of the country from California and we went on this journey all via zoom and FaceTime! I’d you’re considering this, do it! They also graciously give you 7 days to decide, just keep it intact and no modifications and send it back for your money back or exchange! I didn’t mention that I purchased the “style” model and am extremely happy with it. I’ve only had it a week but wow, I’m me again and in minutes flat, I’m ready to go and look like I stepped out of the salon! If you’ve read this all, I wish you luck and congratulations on getting a new you…a gorgeous you, full of confidence!🤗

Dear Tara,

Your review closely touch all of our hearts and we can hope it does the same for others. We are pleased to know Janet was and is able to help you on your journey. Janet is a valuable asset here at Daniel Alain and to all the people she helps. Your kind words and review are the reason we strive to offer the absolute best quality human hair wigs and toppers. We are honored to be apart of your journey and re-gained self confidence.

Thank you for sharing your vulnerable and inspiring experience.

We would love to invite you to join our #FolleaFriend community on Instagram, Where you can share, learn and grow with other amazing Follea friends.

With Love, The Daniel Alain Team.

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Kelly B.
amazing customer service

I cant say enough good things about the customer service I received from Janet. I was nervous cause it was my first time ordering from you on top of that I was getting a custom color, not only was the color spot on, but Janet was sooo patient walking me thru the process
I never felt rushed or hurried to make a decision, honestly she was a dream to work with. Now I'm thinking about the next one I'm going to get;)

Dear Kelly,

Thank you so much for your kind and supportive words. We are glad to know Janet was able to be such a helpful and supportive part of your wig journey. Janet will always be glad to help with any and all questions and concerns you have.

We want to personally invite you to be apart of our @Follea Instagram community where you can Learn, Share, and Grow with other Follea Friends.

Thank you again!
With Love, The Daniel Alain Team

F
Daniel Alain
Felicia J.C.
This is a great wig!

I absolutely love this wig and I wear it with tons of confidence! I purchased my Daniel Alain Follea Style wig on 12/24/20 and it still looks great! I wear wigs regularly due to hair loss and own other good quality wigs but once purchasing this one it has become my favorite wig and I have been wearing it about 5 days a week for over a year and a half. I wash and style it about once a week, use the best hair products available, style it with a T3 curling iron and even had it colored. I admit it is easier to style when on a stand but I have become pretty good at it and have not damaged it one bit, it still looks heathy and so soft. I wear it up, down, braided and even a pony tail, I do have to be a little creative when wearing it up but basically you can do with it whatever you would if it were your own natural hair.
I still love it so much and there is plenty of wear left but I thought it was time for a change and get a new one. When I went on line to look at styles again I realized I never reviewed it and that is why I am reviewing it now. Oh I almost forgot to mention how light and comfortable it is. I have worn it up to 18 hours, slept in it and even wear it on the beach without it feeling hot and sweaty, it really does not feel like you are wearing a wig. If you are on the fence about purchasing a Daniel Alain wig I can tell you it is a very good quality wig and you won't be sorry. Here are a few pics of me styling it and wearing it in different styles, the one of me in blue was last week and about 2 months after coloring it.

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Stacy C.
Simply the Best

I get so many compliments on this wig. The Cappuccino color is so beautiful! I feel so confident when I wear her. I’ve worn so many of the years and I finally feel like I’ve found the one.

Dear Stacy,

We couldn't be happier to hear how beautiful and confident you feel in your new Follea! It warms our hearts to be apart, and a positive affect during your hair loss journey.

We invite you to join our @Follea community on Instagram, to learn best practices for your new Follea. Thank you so much!

XOXO, The Daniel Alain Team

R
Daniel Alain
Ruth T.

Beautiful wigs and the best customer service!!

Dear, Ruth
Thank you so much for your kind words! We take comfort in knowing you were pleased with the help and assistance you received during this process.
Xoxo, The Daniel Alain Team

M
Daniel Alain
M. T.W.
Easy Beauty!

My Follea Style (6-11) is in all honesty the most comfortable wig I've ever worn - and I hate anything on my head! This wig just... goes where it's supposed to, no pulling it this way or that, no realizing your doggone wig is crooked.. AFTER you walk in to work. This success is in no small part to the Fit Kit I was sent to make sure of my size. 😊

Also, to say the hair is beautiful gives beauty a bad name. The hair is stunning. (I wear color Latte.) My consultant, Ashley, virtually took my hand to guide me through the process of buying my wig. Her help was and still is invaluable.

My hairdresser is very comfortable styling wigs. She created just the right "style" for my Style. That said, even straight from the box, Follea rocks!

Reading your Follea experience warms our hearts, our goal and mission is to help women all over the world feel beautiful, confident and like their best self. Ashley is an amazing and knowlegable guide, that will continue to be with you on your hair journey!

We invite you to join our @Follea community on Instagram, to learn best practices for your new Follea.

Thank you very much!

Love,

Daniel Alain Team

K
Daniel Alain
Kimberlee B.
Wig #6

The ready to wear wig I received from Daniel Alain is beautiful. The packaging was so respectful of the wig. So impressed. I called with questions before purchasing and the staff was very kind and respectful as Loosing my hair was so unexpected and stressful. Thank you for wonderful customer service and a beautiful wig. So many compliments on how it makes me look. Thank you.

We are honored and so glad to hear you had a pleasant experience! Thank you or trusting us to help you during your hair-loss journey.

Follea René

Ive had my follea Rene, 12 inch in the color Vienna, for almost a week and I love it more every day. I feel like a new woman, so confident and beautiful again. This wig has given me a bounce in my step again. It’s so soft, silky, doesn’t matte like my other wigs and feels like it is coming right out of my own head. Cynthia at follea did a virtual visit explaining everything, answering all my questions and sent me samples of wig caps and color swatches to try on. The process was stress free and exciting. Will definitely purchase another follea for sure.

Hi Nikki,

Thank you so much for taking the time out of your day to write this review for us. We are so glad to know that you are loving our René wig and more importantly, feeling like confident and beautiful again! Please tag us #danielalain in any photos we'd love to share your amazing look on our website and/or social media platforms.

XO

M
Daniel Alain
Mercedes
Style 10 Inch Color 5005 Macchiato (comes with a soft rooting)

This is my first wig but not my first attempt with alternative hair. Its been a journey and one I knew I wanted to take with Follea. I was not wrong. The hair is silky soft and beautifully shiny. The staff is great and wonderful to work with. Their online consultation process is just what I needed. I received sample caps to try on to determine which size is the right size for me. I received color swatches as well to make the color selection process was a breeze. It does make a difference to see to the colors in person, dont be afraid to ask for color swatches. To see them against the light or while your home is worth it. All this happened after the online consultation, which was simple and fun. The rep provided samples of everything, explained the differences with each one. This helped me make a decision on what was right for me. Getting the samples of the wig caps and color swatches was a fun part of the experience but it also made me feel good about my decisions. I often worry about getting the wrong size and color. Once I was set ( and yes I changed my mind a bit) we went forward with the order. After I received my wig and cut the lace, the team was still there to help me with any questions I had.

Overall a great online purchasing experience. Once I received my Follea, I instantly knew this was it for me. I loved it and I was confident to wear it out.

Feeling Myself and Happy with a beautiful Follea Style, 10", Irish Cream

There are no words to fully express how grateful I am for finding Follea and meeting Janet. Her kindness combined with a professional, yet so gentle, advice helped me to find my beautiful natural looking European hair. Janet patiently showed me different styles and sizes (my head is so small!). She has never pushed me to anything. Only offered support and help on the way to my decision, and eventually ordered (incredibly urgently) the right size. I wish all patients to meet someone like Janet on their way! Before I found Follea, I faced a few horrible pushy people who wanted to make money of my sensitive, fragile situation of suddenly losing hair.
Today, I can face the Universe with a smile, again. I am back to work and normal life, interacting with people, attending important business meetings. Letting my health recover in calm confident state.
Thank You to Follea and Janet. May the Blessing and Kindness come back to You Multiplied Million Times.
I am already thinking of ordering a second Follea Style (bit longer this time). Every girl needs a special occasion HAIR! I have found mine.

e
Daniel Alain
erin g.
Looooove me some FOLLEA!!!

Girl I love my new wig!!!!!! I feel like Beyoncé wearing it, you can’t even tell that it’s a wig! My confidence is an all new high and I feel fierce. Thanks to Janet for making my hair dreams come true. Xoxoxo

H
Daniel Alain
Heather L.
Follea's Petite

Recently, I bought the Petite in Chai Latte blonde with a natural-looking darker root and customized my piece by adding a few wispy bangs. If you are like me and try to stretch the length of time between washes to prevent an itchy scalp and breakage, this little priceless gem is a quick four clips away from a good hair day.

D
Daniel Alain
Diane B.
Great Customer Services

Great customer services! Received in a timely manner. Very happy with my topper, especially after I trimmed bangs and length to fix my own hair.

Hello Diane,

Thank you so much for taking the time out of your day to write this review for us. We are very happy to receive your feedback. Please tag us #danielalain in any photos we'd love to share your amazing look on our website and/or social media platforms.
Feel free to contact us at 1.949.706.9880 or reviews@danielalain.com.

XO